Patient taking Novartis MS pill developed rare disease

ZURICH (Reuters) - A patient taking Novartis' multiple sclerosis pill Gilenya developed a rare and potentially fatal viral disease, the Swiss drugmaker said on Tuesday, an unexpected setback as it faces growing competition from new oral treatments.

Gilenya is one of Novartis' big new drug hopes, growing 66 percent in the second quarter to $468 million. But the drug faces competition from new medicines such as Biogen Idec's Tecfidera.

Novartis said it had been informed of a case of progressive multifocal leukoencephalopathy (PML) in a patient who had been taking Gilenya for MS for seven months.

It said it was working with the reporting physician to understand all possible contributing factors, including those beyond treatment, given several atypical features of the case.

"The course of the underlying neurological disease was rapid with some atypical findings for MS on the MRI scans of the brain and spinal cord, as well as some unusual clinical features," Novartis said in a statement.

Novartis said all previously reported cases of PML among the approximately 71,000 patients treated with Gilenya thus far had been attributed to prior treatment with Biogen Idec's Tysabri, which bears a known risk of PML.

Deutsche bank analyst Tim Race said the case may provoke some concerns about Gilenya's future growth potential. But he noted the incidence of reported PML cases for Gilenya has so far been extremely low.

"By the time there was a similar level of patient experience with Tysabri there had been 298 cases reported. Thus, even if the risk proves to be real it is likely to be of a very different order of magnitude," Race said in a note.

Shares in Novartis were trading down 0.8 percent at 66.10 Swiss francs by 0904 GMT (5.04 a.m. ET), compared to a 0.4 percent weaker European healthcare sector.

(Reporting by Caroline Copley; editing by Patrick Graham)

Source: http://news.yahoo.com/patient-taking-novartis-ms-pill-developed-rare-disease-093138634.html

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99% 20 Feet From Stardom

All Critics (69) | Top Critics (26) | Fresh (67) | Rotten (1)

The movie takes its cues from Standing in the Shadows of Motown, another act of pop-culture revisionism that tried to give musical credit where it was due.

Just about everything in this movie is right. And anybody who gives a rip about unsung heroines of popular music and giving credit when credit's overdue had better come up with a good excuse not to see it.

You may never hear the Rolling Stones's Gimme Shelter the same way again after hearing Jagger's and Clayton's separate accounts of the recording of the song.

The enthusiasm and love of music on display is just unavoidable. "20 Feet" may not get the whole story, but it gets some good ones.

Music documentarian Morgan Neville uses a mix of live interviews and archival footage to let the singers, and their music, tell their stories of vocal triumph and thwarted ambition.

You know all those doo-doo-doos and whoa-whoas-whoas you hear in pop hits? Without them, supplied by the likes of Darlene Love and Merry Clayton, you likely wouldn't be singing along to the songs you hear on your car radio.

Although a few white and male backup singers appear, the film becomes a de facto chronicle of the experiences of many African-American women in show business, who -- like their counterparts in less high-profile jobs -- often are undervalued and exploited.

In a way, critics are the backup singers of film.

20 Feet From Stardom will be highly entertaining to anyone who ever let a needle drop into a '70s-era groove.

Neville does a good job of highlighting songs that are especially characterized by backup singers, like Lou Reed's 'Walk on the Wild Side,' and introducing us to some of the 'unsung' talent that made those hits possible.

This fantastic glimpse into the lives of background singers, old and new, directed by Morgan Neville, is completely mesmerizing.

It is a total pleasure, a rare treat, to listen and watch old footage of these indispensable performers belt out their melodies and harmonies. They are truly pioneers that helped shape the world of music for generations to come.

This is a fascinating doc for pop, soul, R&B and rock fans, for it peels back the often unfair layers of the music business like the skins on an onion. Sometimes, it'll make you cry to witness how terribly these talents were treated.

It's important to finally put names and faces to the voices of these women because, without them, countless songs would sound horrible.

Neville's greatest strength is as a historian, able to sort through a wealth of details to find the pieces he needs to tell one clear, compelling story.

Salutes songs that wouldn't work without the back-ups and, in effect, turn us all into back-up singers.

Not the deepest documentary you're likely to come across this year -- in fact, it's not deep at all -- but it may well be the most enjoyable one.

The transcendent joy and agonizing heartbreak of making music - and trying to make it in music - have seldom been captured as vividly as in "20 Feet from Stardom."

If music has the power to connect, "Twenty Feet From Stardom" shows it's those backup voices making the connection.

Lovers of classic R&B and rock will never get tired of revisiting this movie and its bonanza of performance footage.

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Source: http://www.rottentomatoes.com/m/20_feet_from_stardom/

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Photo of the Alleged Low Cost iPhone With FCC Markings

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Source: http://www.iclarified.com/32279/photo-of-the-alleged-low-cost-iphone-with-fcc-markings

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Aljamaaheer set to take on Caspar Netscher at Goodwood ...

Aljamaaheer set to take on Caspar Netscher at Goodwood ? Horseracing news

Aljamaaheer is set to take on Caspar Netscher in the Group 2 bet365 Lennox Stakes at Goodwood in England.

The latter of the two has been out of action for quite some time and it will be interesting to see how he goes in such a tough race on his comeback. Things will certainly not be easy for him, especially if the ground is challenging.

His camp seems pretty much confident though and his trainer David Simcock said, ?Caspar Netscher is set to run at Goodwood. He has settled in well and I couldn't be happier with him. He has proven very straightforward but we haven't rushed him. He was a horse who was let down to become a stallion and the likelihood is that he will improve for the run.?

The four-year-old colt has appeared in a total of 16 races and his performances in them have not been bad at all. Although his strike rate is a touch lower, he is considered to be a terrific performer and can cause plenty of problems for his rivals, especially when the conditions are in his favour.

Overall, he has managed to win five races, which is not a bad record at all. Moreover, he has finished as a runner up on a couple of times whereas secured the third spot on the same number of occasions.

On the other hand, Aljamaaheer has been doing a pretty good job this year. He is fit and has taken part in a couple of extremely important competitions for his camp. He ran twice at Ascot this season and made his camp proud on both occasions. He finished as a runner up once, but came back to take the top spot again.

Looking at the records of both stallions, it seems that the competition amongst them will be a close one, but the ground conditions will play a crucial role.

Clerk of the course Seamus Buckley claimed, ?We have been dry since 11am yesterday and I am very happy with the condition of the course. Glorious Goodwood is a long week and it is the aim to start the meeting on goodish ground.?

All of the horseracing fans at Goodwood will be looking forward to an exciting competition between some high ranked stallions.

Source: http://blogs.bettor.com/Aljamaaheer-set-to-take-on-Caspar-Netscher-at-Goodwood-Horseracing-news-a217832

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Start Your Engine? at the Touch of a Button : NYE Auto

Posted by NYE Automotive Group on Thursday, July 25, 2013 ? Leave a Comment?

Ever marveled at the old electric start button on your snow blower and wished you could have the same thing on your vehicle? It would be simplicity itself to start it ? and you could forever avoid that dreaded grinding noise when you accidentally turn the key when the engine is already started? (come on, we?ve all done that once or twice ?)

The Nye Automotive Group is pleased to be able to offer the most cutting edge technology of the latest cars, trucks, SUVs, and vans, and now the Ford Motor Company has eliminated the fumbling for keys with the push-button convenience of available Intelligent Access on several of their latest models. The feature needs only the presence of the key fob in a pocket or purse, or anywhere else on your person, to open the doors and get the engine to start.

Even before you get in, simply by clutching the door handle you activate the communication between the key fob and the vehicle?s computer. There is a silent signal sent between the two computerized mechanisms, and once the proper coding is recognized the door unlocks automatically ? with the vehicle?s key still snugly put away.

It?s not magic, but cutting edge modern technology Henry Ford never dreamed of in his wildest invention inspirations. It doesn?t end there ?you climb inside and activate the engine security mechanism by pressing the brake pedal. Then as you push the start button on the dashboard, the onboard computer communicates with that key fob ? still secure in the safety of your pocket or wherever ? to send a signal to the engine that it is okay to fire up. That prevents unauthorized persons from attempting to activate the vehicle by pushing the button, because the safety feature prohibits the startup without a proper fob within range.

Intelligent Access is available on the 2013 C-Max, Focus, and Edge, and the 2014 Explorer, Escape, Flex, Taurus, and Fiesta. Come to NYE today to experience this modern wonder of automotive technology for yourself.

The NYE Automotive Group is located at 1479 Genesee St. in Oneida, N.Y. For more info on any of our vehicles and services, call (315) 363-0600 or email sales@nyeauto.com.

Source: http://nyeauto.com/start-your-engine-at-the-touch-of-a-button/

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Iraq to import natural gas from Iran

BAGHDAD (AP) -- An Iraqi government spokesman says Baghdad has signed a deal with Iran to import natural gas for power generation, further intertwining the economies of the two Shiite-dominated countries.

Electricity Ministry spokesman Musab al-Mudaris said Tuesday that the four-year deal stipulates that Iraq buy 850 million cubic feet a day of gas at international market prices.

Al-Mudaris added that the gas will be shipped through a pipeline which will be completed in the coming two months. He said the gas will feed a power plant in Diyala province east of Baghdad and two others in the capital to generate 2,500 MW. The deal was signed in Baghdad on Sunday.

Iraq has spent billions of dollars to rebuild its dilapidated electrical grid since the 1990s, but Iraqis still suffer chronic power outages.

Source: http://news.yahoo.com/iraq-import-natural-gas-iran-104340245.html

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2013 Fiat 500E Is Northwest Automotive Press Association's First ...

Congregating in the United States? largest concentration of charging stations per capita, the Northwest Automotive Press Association (NWAPA) said its members voted the all-new 2013 Fiat 500e their ?Top Electric Vehicle? at the first-annual ?Drive Revolution? green-car event in Portland.

Considering the area?s reputation for being a green-vehicle hub, NWAPA said its members tested 17 of the market?s most technologically advanced and fuel efficient models around Portland ? including electric cars, plug-in hybrids, and clean-diesel models from both import and domestic manufacturers.

?The Fiat 500e is an electric car with sex appeal,? said Bengt Halvorson, Drive Revolution Event Co-chair. ?Unlike other electric vehicles, we think the Fiat 500e will lure in a type of buyer that otherwise might not even have considered a plug-in model.?

While the Fiat 500e is currently available in California only, NWAPA members see great appeal for this zero-emission, battery-electric Cinquecento (500) for American big-city commuters everywhere.

?We wanted a Fiat 500 that happens to be fully electric,? said Jason Stoicevich, Head of Fiat Brand-North America. ?NWAPA?s Drive Revolution accolade reinforces that our Italian style and engaging dynamics, combined with a fully electric powertrain, have created a zero-emissions Cinquecento that appeals beyond just green car shoppers.?

Source: http://www.hybridcars.com/2013-fiat-500e-is-northwest-automotive-press-associations-first-ever-top-electric-vehicle-pick/

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